P9375
Sigma-Aldrich

1,10-Phenanthroline monohydrate

reagent grade

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Synonym

o-Phenanthroline monohydrate

Molecular Formula

C₁₂H₈N₂ · H₂O

Molecular Weight

198.22

CAS Number

5144-89-8

Beilstein Registry Number

4008096

MDL number

MFCD00149973

PubChem Substance ID

24278663

EG/EC Number

200-629-2

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Descriptions

Application

When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.

Biochem/physiol Actions

Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.

Properties

grade

reagent grade

100-104 °C(lit.)

solubility

methanol: 200 mM Stock solution is stable for months at –20° C.

References

Reference

Sigman, D.S., et al., Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions. Meth. Enzymol. 208, 414-433, (1991)

Santiago, T.C. et al., The relationship between mRNA stability and length in Saccharomyces cerevisiae. Nucleic Acids Res. 14, 8347, (1986)

, Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach, (1989), 246

Beilstein

Beil. 23,V,8,419

reference

Aldrich MSDS 1, 1447:A / Corp MSDS 1 (2), 2738:B / FT-IR 2 (3), 3960:B / FT-IR 1 (2), 890:A / IR-Spectra (3), 1411:A / IR-Spectra (2), 1231:B / RegBook 1 (2), 2653:L / Sax 6, 2155 / Sigma FT-IR 1 (2), 192:C / Stains and Dyes Ref, 559 / Structure Index 1, 417:A:8

Safety

Hazard Codes

T,N

Risk Statements

25-50/53

Safety Statements

45-60-61

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

SF8437000

Related Categories

... A to C > Aminopeptidase N

... Protease Inhibitor Specificity Index > Carboxypeptidase A

... A to C > Carboxypeptidase A

... Protease Inhibitor Specificity Index > Carboxypeptidase B

... A to C > Carboxypeptidase B

... D to K > Deoxyribonuclease I

... Protease Inhibitor Specificity Index > Dispase

... Essential Biological Reagents > Enzyme Inhibitors

... D to K > Galactosidase, beta-

... D to K > Glyoxalase I

... D to K > Isocitric dehydrogenase (NADP)

... Protease Inhibitor Specificity Index > Leucine aminopeptidase, cytosol

... L to O > Leucine aminopeptidase, cytosol

... L to O > Mannosidase, alpha-

... Broad Spectrum Inhibitors of Proteolytic Enzyme Classes > Metalloproteinase Inhibitors

... L to O > NADH peroxidase

... L to O > Nucleotidase, 5'-

... P to Q > Phosphatase, Alkaline - Inhibitors

... P to Q > Phosphodiesterase I

... P to Q > Phospholipase A 2

... P to Q > Phospholipase C

... Protease Inhibitors > Protease Inhibitors

... Native Protein Sample Preparation > Protease Inhibitors

... Protease Inhibitor Specificity Index > Thermolysin

... R to Z > Thermolysin

Dopamine, Norepinephrine Metabolism (90kb)

P9375 - Product Information Sheet (67kb)

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information