S0929
Sigma-Aldrich

Scopolamine hydrobromide

meets USP testing specifications

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Synonym

(−)-Scopolamine hydrobromide trihydrate

Hyoscine hydrobromide

Scopine tropate

Molecular Formula

C₁₇H₂₁NO₄ � HBr � 3H₂O

Molecular Weight

438.31

CAS Number

6533-68-2

Beilstein Registry Number

6100669

MDL number

MFCD00150066

PubChem Substance ID

24899453

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Descriptions

Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Properties

195-199 °C (dry matter)(lit.)

suitability

meets USP testing specifications

References

Reference

Park, C.H., et al., Dehydroevodiamine.HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J. Neurochem. 74, 244-253, (2000)

Rush, D.K., Scopolamine amnesia of passive avoidance: a deficit of information acquisition. Behav. Neural Biol 50, 255-274, (1988)

Frey, K.A., and Howland, M.M.,, Quantitative autoradiography of muscarinic cholinergic receptor binding in the rat brain: distinction of receptor subtypes in antagonist competition assays. J. Pharmacol. Exp. Ther. 263, 1391-1400, (1992)

Beilstein

Beil. 27,I,242

Safety

Hazard Codes

T+

Risk Statements

26/27/28

Safety Statements

25-45

RIDADR

UN 1544 6.1/PG 3

WGK Germany