T8516
Sigma-Aldrich

Trifluoperazine dihydrochloride

≥99%, powder

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Synonym

10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride

Molecular Formula

C₂₁H₂₄F₃N₃S · 2HCl

Molecular Weight

480.42

CAS Number

440-17-5

Beilstein Registry Number

3820024

MDL number

MFCD00012656

PubChem Substance ID

24277943

EG/EC Number

207-123-0

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Descriptions

Biochem/physiol Actions

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3':5'-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Properties

assay

≥99%

form

powder

color

white

243 °C (dec.)(lit.)

Gene Information

human ... DRD2(1813)

storage temp.

−20°C

References

Reference

Carballo, M, Characterization of calcineurin in human neutrophils Inhibitory effect of hydrogen peroxide on its enzyme activity and on NF-κB DNA binding. J. Biol. Chem. 274, 93, (1999) abstract

Mach, R.L., et al., Ca²⁺-calmodulin antagonists interfere with xylanase formation and secretion in Trichoderma reesei. Biochim. Biophys. Acta 1403, 281-289, (1998) abstract

Samouilidou, E.C., et al., The sarcolemmal Ca²⁺-ATPase of the ischemic-reperfused myocardium: protective effect of hypocalcemia on calmodulin-stimulated activity. Life Sci. 62, 29-36, (1998) abstract

Merck

Merck 13,9753

Beilstein

Beil. 27,IV,1353

reference

Corp MSDS 1 (2), 3437:D / FT-IR 2 (2), 2236:A / FT-NMR 1 (2), 669:C / RegBook 1 (1), 1533:I / Sigma FT-IR 1 (2), 946:B / Structure Index 1, 239:C:5

Safety

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

RTECS

SP1750000

3-10

Related Categories

... Intracellular Calcium Signaling > Calcium Antagonists

... Xenobiotics and Drug Metabolism > Substrates

MSDS

Specification Sheet

Certificate of Analysis

More Information