A0326
Sigma

(S)-AMPA

≥98%

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Synonym

(S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

Molecular Formula

C₇H₁₀N₂O₄

Molecular Weight

186.17

CAS Number

83643-88-3

MDL number

MFCD00672630

PubChem Substance ID

24890421

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Descriptions

Biochem/physiol Actions

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

Properties

assay

≥98%

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897)

rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grin2b(24410), Grm6(24419)

mouse ... Gria1(14799)

References

Reference

Patel, D.R., et al., Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat forebrain. Eur. J. Pharmacol. 332, 143-151, (1997) abstract

Lauridsen, et al., Ibotenic acid analogues. Synthesis, molecular flexibility and in vitro activity of agonists and antagonists at central glutamic acid receptors. J. Med. Chem. 28, 668, (1985) abstract

Hawkinson, J.E., et al., Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine (S)-AMPA and (R,S)-AMPA binding. Eur. J. Pharmacol. 329, 213, (1997) abstract

Safety

WGK Germany

Related Categories

... Excitatory Amino Acids > AMPA/Kainate Agonists

... Ligand-Gated Ion Channels > Ionotropic Glutamate Receptor Modulators

Glutamate Receptors Ion Channel Family (188 kb)

Celltransmissions 19(1) (178kb)

MSDS

Certificate of Analysis

Certificate of Origin

More Information