A1439
Sigma

Pituitary adenylate cyclase activating polypeptide-38

Synonym

PACAP-38

Amino Acid Sequence

His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH₂

Molecular Formula

C₂₀₃H₃₃₁N₆₃O₅₃S

Molecular Weight

4534.26

CAS Number

137061-48-4

MDL number

MFCD00081800

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Descriptions

Biochem/physiol Actions

A neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). Both VIP and PACAP-38 are equipotent at the VCAP-2 receptor, while PACAP-38 is equipotent to PACAP-27 and more potent than VIP at the PAC-1 receptor.

Legal Information

Sold under license to US patent number 5,128,242

Properties

composition

Peptide content, ~70%

Gene Information

human ... ADCYAP1(116)

storage temp.

−20°C

References

Reference

Tornoe, K., et al., PACAP-(1-38) as neurotransmitter in the porcine adrenal glands. Am. J. Physiol. Endocrinol. Metab. 279, E1413-E1425, (2000) abstract

Kinhult, J., et al., Pituitary adenylate cyclase-activating peptide 38 a potent endogenously produced dilator of human airways. Eur. Respir. J. 15, 243-247, (2000) abstract

Dickinson, T., et al., The role of VIP/PACAP receptor subtypes in spinal somatosensory processing in rats with an experimental peripheral mononeuropathy. Neuropharmacology 38, 167-180, (1999) abstract

Yada, T., et al., Pituitary adenylate cyclase-activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet βcells. J. Biol. Chem. 269, 1290-1293, (1994) abstract

Martinez-Fuentes, A.J., et al., Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP27 activate common and distinct intracellular signaling pathways to stimulate growth hormone secretion from porcine somatotropes. Endocrinology 139, 5116-5124, (1998) abstract

Lutz, E.M., et al., Domains determining agonist selectivity in chimaeric VIP2 (VPAC2)/PACAP (PAC1) receptors. Br. J. Pharmacol. 128, 934-940, (1999) abstract

Safety

WGK Germany