A1663
Sigma

Atrial Natriuretic Peptide human

≥97% (HPLC)

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Synonym

ANF 1-28

hANF

Urodilatin

Amino Acid Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]

Molecular Formula

C₁₂₇H₂₀₃N₄₅O₃₉S₃

Molecular Weight

3080.44

CAS Number

91917-63-4

MDL number

MFCD00076226

PubChem Substance ID

24890580

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Descriptions

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Properties

assay

≥97% (HPLC)

Gene Information

human ... NPPA(4878)

storage temp.

−20°C

References

Reference

Palluk, R., et al., Atrial natriuretic factor. Life Sci. 36, 1415-1425, (1985)

Potter, L.R., and Hunter, T., Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19, 506-520, (1999)

Potter, L.R. and Hunter, T., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194, 1, (2000)

Thibault, G., et al., Regulation of natriuretic peptide secretion by the heart. Annu. Rev. Physiol. 61, 193, (1999)

Gonzalez Bosc, L.V., Effects of atrial natriuretic peptide in the gut. Peptides 21, 875, (2000)

Safety

WGK Germany