A1705
Sigma

S-(5′-Adenosyl)-L-homocysteine Hydrolase from rabbit erythrocytes

buffered aqueous glycerol solution, ≥10 units/mg protein (Lowry)

CAS Number

9025-54-1

Enzyme Commission (EC) Number

3.3.1.1 ( BRENDA | IUBMB )

MDL number

MFCD00132212

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Descriptions

Biochem/physiol Actions

Enzyme in vertebrates which catabolizes S-adenosyl-L-homocysteine.

Unit Definition

One unit will hydrolyze 1.0 nanomole of S-adenosyl-L-homocysteine to adenosine and L-homocysteine per min at pH 7.2 at 37 °C.

Physical form

Solution in 25 mM Tris, pH 7.4, containing 1 mM dithiothreitol, 1 mM EDTA, and 20% glycerol.

Properties

form

buffered aqueous glycerol solution

foreign activity

Adenosine deaminase activity ≤1%

shipped in

dry ice

storage temp.

−70°C

References

Reference

Stockand, J.D., et al., S-adenosyl-L-homocysteine hydrolase regulates aldosterone-induced Na⁺ transport. J. Biol. Chem. 274, 3842-3850, (1999) abstract

Robins, M.J., et al., Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5′5′6′6′-tetradehydro-6′-deoxy-6′-halohomoadenosine analogues (4′-haloacetylene analogues derived from adenosine). J. Med. Chem. 41, 3857-3864, (1998) abstract

Safety

WGK Germany

Related Categories

... Gene Regulation and Expression > Gene Regulation

... General Metabolic Enzymes > General Metabolic Enzymes A-H

... 3.x.x.x Hydrolases > 3.3.x.x Acting on ethers

Metabolic Pathways Chart (784 kb)

A1705 - Enzyme Assay (11kb)

MSDS

Specification Sheet

Certificate of Analysis

Certificate of Origin

More Information