A1802
Sigma

des(Gln¹⁸, Ser¹⁹, Gly²⁰, Leu²¹, Gly²²)-Atrial natriuretic peptide fragment 4-23 amide rat

≥95% (HPLC)

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Amino Acid Sequence

Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Cys-NH₂ [Disulfide Bridge: 4—15]

Molecular Formula

C₆₄H₁₀₇N₂₅O₁₉S₂

Molecular Weight

1594.82

CAS Number

111863-73-1

MDL number

MFCD00076231

PubChem Substance ID

24890590

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Descriptions

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Properties

assay

≥95% (HPLC)

Gene Information

rat ... Nppa(24602)

storage temp.

−20°C

References

Reference

Palluk, R., et al., Atrial natriuretic factor. Life Sci. 36, 1415-1425, (1985)

Potter, L.R., and Hunter, T., Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19, 506-520, (1999)

Thibault, G., et al., Regulation of natriuretic peptide secretion by the heart. Annu. Rev. Physiol. 61, 193, (1999)

Potter, L.R. and Hunter, T., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194, 1, (2000)

Gonzalez Bosc, L.V., Effects of atrial natriuretic peptide in the gut. Peptides 21, 875, (2000)

Safety

WGK Germany