A2275
Sigma

[Sar¹, Val⁵, Ala⁸]-Angiotensin II acetate hydrate

≥97% (HPLC), powder

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Synonym

Saralasin

Amino Acid Sequence

Sar-Arg-Val-Tyr-Val-His-Pro-Ala

Molecular Formula

C₄₂H₆₅N₁₃O₁₀ · xC₂H₄O₂ · yH₂O

Molecular Weight

912.05 (anhydrous free base basis)

MDL number

MFCD00133980

PubChem Substance ID

24890641

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Descriptions

Biochem/physiol Actions

Competitive angiotensin II antagonist; inhibits pressor effects of angiotensin II in rats and lowers blood pressure in humans.

Properties

assay

≥97% (HPLC)

form

powder

Gene Information

human ... AGTR1(185)

rat ... Agtr1a(24180)

storage temp.

−20°C

References

Reference

Matsubara, S., et al., Evidence for the AT1 subtype of the angiotensin II receptor in the rat submandibular gland. Biol. Pharm. Bull. 23, 1185-1188, (2000) abstract

de Arruda Camargo, L.A., and Saad, W.A.,, Renal effects of angiotensin II receptor subtype 1 and 2-selective ligands injected into the paraventricular nucleus of conscious rats. Regul. Pept. 84, 91-96, (1999) abstract

Timmermans, P.B., and Smith, R.D., A new class of therapeutic agents: the angiotensin II receptor antagonists. Cardiologia 39, 397-400, (1994) abstract

Safety

WGK Germany