Apolipoprotein E4 human 

Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins. It regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. It binds to LDL receptors and particles containing apolipoprotein E4 and also binds amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain.

Human recombinant Apo E4 competes with iodinated human low density lipoprotein for binding to the human Apo B/E (LDL) receptor.

Solution in 0.7 M ammonium bicarbonate.

expressed in baculovirus infected Spodoptera frugiperda cells

buffered aqueous solution

human ... APOE(348)

−20°C

Corder, E.H., et al. Science 261, 921, (1993)

Evans, K.C., et al. Proc. Natl. Acad. Sci. USA 92, 763, (1995)

Gretch, D., et al. Proc. Natl. Acad. Sci. USA 88, 8530, (1991)

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