Apolipoprotein E2 human 

Human recombinant Apo E2 competes with iodinated human low density lipoprotein for binding to the human Apo B/E (LDL) receptor. Human recombinant Apo E also binds to β-amyloid peptide in a soluble binding assay.

Solution in 0.7 M ammonium bicarbonate.

Apolipoprotein E2 is a member of the apolipoprotein E family of plasma lipoproteins. It regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. It binds to LDL receptors, and particles containing apolipoprotein E2 bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Compared to apolipoprotein E3, apolipoprotein E2 is associated with lower plasma LDL levels and may protect against the development of atherosclerosis. Apolipoprotein E2 also appears to be associated with reduced risk for Alzheimer′s disease.

expressed in baculovirus infected Sf cells

≥90% (SDS-PAGE)

buffered aqueous solution

mol wt ~34 kDa

human ... APOE(348)

−20°C

Cole, G.M., Ard, M.D., Influence of lipoproteins on microglial degradation of Alzheimer's amyloid β-protein. Microsc. Res. Tech. 50, 316, (2000) abstract

Mahley, R.W., Huang, Y., Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10, 207, (1999) abstract

Horejsi, B., Ceska, R., Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis. Physiol. Res. 49 Suppl. 1, (2000)

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