A4933
Sigma

Astressin

≥90% (HPLC)

Synonym

[D-Phe¹², Nle^21,38, Glu³⁰, Lys³³]-Corticotropin Releasing Factor fragment 12-41

Amino Acid Sequence

D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo-(-γ-Glu-Ala-His-ε-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH₂

Molecular Formula

C₁₆₁H₂₆₉N₄₉O₄₂

Molecular Weight

3563.16

CAS Number

170809-51-5

MDL number

MFCD00798715

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Descriptions

Biochem/physiol Actions

Highly potent CRF antagonist.

Properties

assay

≥90% (HPLC)

storage temp.

−20°C

References

Reference

Gulyas, J., et al., Potent structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc. Natl. Acad. Sci. USA 92, 10575, (1995) abstract

Ha, B.K., et al., Corticotropin releasing factor induces proliferation of cerebellar astrocytes. J. Neurosci. 62, 789-798, (2000)

Sajdyk, T.J., and Gehlert, D.R., Astressin, a corticotropin releasing factor antagonist, reverses the anxiogenic effects of urocortin when administered into the basolateral amygdala. Brain Res. 877, 226-234, (2000) abstract

Safety

WGK Germany

Related Categories

... Releasing Factors > CRF

Celltransmissions 19(4) (484kb)

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A4933 (Sigma)