A5157
Sigma

DL-2-Amino-7-phosphonoheptanoic acid

~95%

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Synonym

AP-7

Molecular Formula

C₇H₁₆NO₅P

Molecular Weight

225.18

CAS Number

85797-13-3

MDL number

MFCD00055057

PubChem Substance ID

24277980

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Descriptions

Biochem/physiol Actions

Selective NMDA glutamate receptor antagonist; anticonvulsant.

Properties

assay

~95%

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

rat ... Grin2a(24409), Grin2b(24410)

References

Reference

Benveniste, et al., Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: The influence of conformational restriction. Br. J. Pharmacol. 104, 207, (1991) abstract

Bazil, et al., Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla. Am. J. Physiol. 260, H267, (1991) abstract

Stone., The relative potencies of (–)-2-amino-5 phosphonovalerate and (–)-2-amino-7-phosphonoheptanoate as antagonists of N-methylaspartate and quinolinic acids and repetitive spikes in rat hippocampal slices. Brain Res. 381, 195, (1986) abstract

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

MJ1927500