A6553
Sigma

DL-2-Amino-5-phosphonovaleric acid lithium salt

~95%

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Synonym

DL-2-Amino-5-phosphonopentanoic acid

AP-5

Molecular Formula

C₅H₁₁NO₅PLi

Molecular Weight

203.06

CAS Number

125229-62-1

MDL number

MFCD00078901

PubChem Substance ID

24891104

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Descriptions

Biochem/physiol Actions

Anticonvulsant; potent and selective antagonist for NMDA receptors.

Properties

assay

~95%

Gene Information

rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)

References

Reference

Hara, S., et al., Distinct effects of MK-801 and (±)-2-amino-5-phosphonopentanoic acid on N-methyl-D-aspartate-induced rise of brain temperature in rats. Life Sci. 61, 289-294, (1997)

McNally, G., et al., Effects of systemic, intracerebral, or intrathecal administration of an N-methyl-D-aspartate receptor antagonist on associative morphine analgesic tolerance and hyperalgesia in rats. Behav. Neurosci. 112, 966, (1998)

Baunez, C. and Amalric, M., Evidence for functional differences between entopeduncular nucleus and substantia nigra: effects of APV (DL-2-amino-5-phosphonovaleric acid) microinfusion on reaction time performance in the rat. Eur. J. Neurosci. 8, 1972-1982, (1996)

Watkins, J.C. and Evans, R.H., Excitatory amino acid transmitters. Annu. Rev. Pharmacol. Toxicol. 21, 165-204, (1981)

Safety

WGK Germany