A6791
Sigma

Atrial Natriuretic Peptide fragment 3-28 rat

≥97% (HPLC)

Synonym

ANP

rANF 3-28

Amino Acid Sequence

Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]

Molecular Formula

C₁₁₉H₁₈₉N₄₃O₃₆S₂

Molecular Weight

2862.17

CAS Number

90984-99-9

MDL number

MFCD00076230

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Descriptions

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Properties

assay

≥97% (HPLC)

Gene Information

rat ... Nppa(24602)

storage temp.

−20°C

References

Reference

Palluk, R., et al., Atrial natriuretic factor. Life Sci. 36, 1415-1425, (1985)

Winquist, R.J., et al., Vasodilator profile of synthetic atrial natriuretic factor. Eur. J. Pharmacol. 102, 169-173, (1984)

Thibault, G., et al., Regulation of natriuretic peptide secretion by the heart. Annu. Rev. Physiol. 61, 193, (1999)

Gonzalez Bosc, L.V., Effects of atrial natriuretic peptide in the gut. Peptides 21, 875, (2000)

Potter, L.R. and Hunter, T., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194, 1, (2000)

Potter, L.R., and Hunter, T., Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19, 506-520, (1999)

Safety

WGK Germany

3

Related Categories

... Miscellaneous Peptides > Guanylate Cyclase Activators

... Peptides for Cell Biology > Natriuretic Peptides

... Functional Profiling of Stem Cells > Protein profiling

... Cardiac Stem Cell Expansion and Differentiation > Proteins, Peptides, & Hormones

... Bioactives/Supplements > Vitamins, Hormones, Misc.