Angiogenin human 

The activity of human angiogenin is tested in culture by measuring its ribonucleolytic activity for yeast tRNA.¹

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily. Although the ribonucleolytic activity of angiogenin toward most RNase A substrates is lower than that of RNase A, this activity is essential to its angiogenic activity since inhibition of the angiogenin RNase activity will inhibit the angiogenic activity. High affinity receptors for angiogenin are expressed in cultured aortic smooth muscle cells and can be modulated by protamin, heparin and placental ribonuclease inhibitor.

Angiogenin, a liver-derived angiogenic factor, is a single chain polypeptide with an isoelectric point of pl >9.5 and a member of the ribonuclease superfamily.

expressed in Escherichia coli

≥97% (SDS-PAGE)

lyophilized powder

mol wt 14.4 kDa

Endotoxin, tested

cell culture tested

human ... ANG(283)

−20°C

1. Hatzi, E., and Badet, J., Expression of receptors for human angiogenin in vascular smooth muscle cells. Eur. J. Biochem. 260, 825, (1999) abstract

Strydom, D.J., The angiogenins. Cell. Mol. Life Sci. 54, 811, (1998) abstract

Badet, J., Angiogenin, a potent mediator of angiogenesis: biological and structural properties. Pathol. Biol. 47, 345, (1999) abstract

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