A8013
Sigma

L-Arginase from bovine liver

lyophilized powder, 150-250 units/mg protein

Synonym

L-Arginine amidinase

L-Arginine amidino-hydrolase

CAS Number

9000-96-8

Enzyme Commission (EC) Number

3.5.3.1 ( BRENDA | IUBMB )

MDL number

MFCD00081368

EG/EC Number

232-570-3

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Descriptions

Unit Definition

One unit will convert 1.0 μmole of L-arginine to ornithine and urea per min at pH 9.5 at 37 °C.

Physical form

Lyophilized powder containing manganous sulfate and sodium maleate.

Biochem/physiol Actions

The major degradative enzyme for arginine; converts arginine to ornithine; deficiency is associated with spasticity and motor dysfunction.

Properties

form

lyophilized powder

composition

Protein, ≥70% biuret

Gene Information

cow ... ARG2(518752)

storage temp.

−20°C

References

Reference

Rouzaut, A., et al., Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO. Biochim. Biophys. Acta 1451, 319-333, (1999) abstract

Bewley, M.C., et al., Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily. Structure 7, 435-448, (1999) abstract

Salimuddin, et al., Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide. Am. J. Physiol. 277, E110, (1999) abstract

Boucher, J.L., et al., Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol. Life Sci. 55, 1015-1028, (1999)

Safety

WGK Germany

10-21