A8208
Sigma

Atrial Natriuretic Peptide rat

≥97% (HPLC)

zoom

1 of 1

Synonym

α-Atriopeptin, rat

α-rANP

ANF (123-150), rat

ANF 1-28

rANP

Amino Acid Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7—23]

Molecular Formula

C₁₂₈H₂₀₅N₄₅O₃₉S₂

Molecular Weight

3062.41

CAS Number

88898-17-3

MDL number

MFCD00076228

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

Properties

assay

≥97% (HPLC)

composition

Peptide content, ≥70%

Gene Information

rat ... Nppa(24602)

storage temp.

−20°C

References

Reference

Palluk, R., et al., Atrial natriuretic factor. Life Sci. 36, 1415-1425, (1985)

Potter, L.R., and Hunter, T., Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19, 506-520, (1999)

Thibault, G., et al., Regulation of natriuretic peptide secretion by the heart. Annu. Rev. Physiol. 61, 193, (1999)

Gonzalez Bosc, L.V., Effects of atrial natriuretic peptide in the gut. Peptides 21, 875, (2000)

Potter, L.R. and Hunter, T., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194, 1, (2000)

Safety

Safety Statements

22-24/25

WGK Germany

Related Categories

... Neuropeptides > Natriuretic Peptides

... Peptides for Cell Biology > Natriuretic Peptides

... Cardiac Stem Cell Expansion and Differentiation > Proteins, Peptides, & Hormones

MSDS

Specification Sheet

Certificate of Analysis

More Information