Activin Receptor IIA human 

The biological activity is measured by its ability to inhibit hemoglobin expression induced by activin in K562 cells.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5 mg bovine serum albumin.

Activin isoforms are members of the TGF-β superfamily that bind to heteromeric complexes of a type I and a type II serine/threonine kinase receptor, both of which are essential for signal transduction. In addition to the activin isoforms, activin receptor II binds inhibin, BMP-2 and BMP-7. Human, murine and rat type II activin receptors demonstrate greater than 98% homology.

expressed in Sf21 cells

>95% (SDS-PAGE)

lyophilized powder

Endotoxin, tested

human ... ACVR2A(92)

−20°C

Attisano, L., et al., Activation of signaling by the activin receptor complex. Mol. Cell. Biol. 16, 1066, (1996) abstract

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