A9165
Sigma

N-Acetyl-L-cysteine

cell culture tested

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Synonym

LNAC

NAC

Molecular Formula

HSCH₂CH(NHCOCH₃)CO₂H

Molecular Weight

163.19

CAS Number

616-91-1

Beilstein Registry Number

1724426

MDL number

MFCD00004880

PubChem Substance ID

24891402

EG/EC Number

210-498-3

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Descriptions

Frequently Asked Questions

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Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Properties

106-108 °C(lit.)

solubility

H₂O: 100 mg/mL with heating

suitability

cell culture tested

storage temp.

2-8°C

References

Reference

Ferrari, G., et al., N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15, 2857-2866, (1995)

Weinander, R., et al., Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase. A study of thiol ligands. J. Biol. Chem. 269, 71-76, (1994)

Roederer, M., et al., Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc. Natl. Acad. Sci. USA 87, 4884-4888, (1990)

Tsai, J.C., et al., Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J. Biol. Chem. 271, 3667-3670, (1996)

Merck

Merck 13,90

Beilstein

Beil. 4,IV,3160

reference

FT-IR 2 (1), 1332:A / FT-IR 1 (1), 786:D / FT-NMR 1 (1), 1282:B / IR-Spectra (3), 466:D / IR-Spectra (2), 413:E / NMR-Reference 2 (1), 659:D / RegBook 1 (1), 919:G / Sax 6, 107 / Sigma FT-IR 1 (1), 4:A / Structure Index 1, 142:C:7

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

HA1660000

10-23