Activin Receptor IB human 

Activin receptor IB/Fc chimera does not bind directly to activin or inhibin but will associate with the type II receptor-activin complex and initiate signal transduction. Type I receptor-activins also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin isoforms are members of the TGF-β superfamily that bind to heteromeric complexes of type I and type II serine/threonine kinase receptor, both of which are essential for signal transduction. Human, murine and bovine type IB activin receptors demonstrate greater than 98% homology.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

expressed in mouse NSO cells

>90% (SDS-PAGE)

lyophilized powder

Endotoxin, tested

human ... ACVR1B(91)

−20°C

Attisano, L., et al., Activation of signaling by the activin receptor complex. Mol. Cell. Biol. 16, 1066, (1996) abstract

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