A9808
Sigma

Pituitary adenylate cyclase activating polypeptide-27 ovine

≥97% (HPLC), solid

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Synonym

PACAP-27

Amino Acid Sequence

His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH₂

Molecular Formula

C₁₄₂H₂₂₄N₄₀O₃₉S

Molecular Weight

3147.61

CAS Number

127317-03-7

MDL number

MFCD00167418

PubChem Substance ID

24891501

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Descriptions

Biochem/physiol Actions

Neuropeptide that stimulates both adenylate cyclase in cultured pituitary cells and insulin release from pancreatic islet β-cells. Increases cAMP levels; increases tyrosine hydroxylase expression in chromaffin cells.

Legal Information

Sold under license to US patent number 5,128,242

Properties

assay

≥97% (HPLC)

form

solid

composition

Peptide content, ~70%

color

white

Gene Information

sheep ... PACAP(443337)

storage temp.

−20°C

References

Reference

Rawlings, et al., Pituitary adenylate cyclase activating polypeptide increases [Ca²⁺]in rat gonadotrophs through an inositol trisphosphatedependent mechanism. J. Biol. Chem. 269, 5680, (1994) abstract

Yada, et al., Pituitary adenylate cyclase-activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet βcells. J. Biol. Chem. 269, 1290-1293, (1994) abstract

Koch, et al., Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates cyclic AMP formation as well as peptide output of cultured pituitary melanotrophs and AtT20 corticotrophs. Regul. Pept. 38, 45, (1992) abstract

Safety

WGK Germany

Related Categories

... Miscellaneous Peptides > Adenylate Cyclase Activators

... Cyclic Nucleotide Metabolism > Adenylyl Cyclase Activators

... Peptides for Cell Biology > Vasoactive Intestinal Peptides

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