A9847
Sigma

Angiopoietin-2 human

>97% (SDS-PAGE), recombinant, expressed in mouse NSO cells, lyophilized powder

Synonym

Ang-2

MDL number

MFCD01867019

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Descriptions

Analysis Note

The biological activity is measured by its ability to bind immobilized Tie-2/Fc in a functional ELISA assay.

Biochem/physiol Actions

This ligand is a naturally occurring inhibitor of angiopoietin-1 and Tie-2 both in vivo and in vitro, and has important roles in embryogenic angiogenesis and maintaining the integrity of adult vasculature.

Physical form

Lyophilized from a 0.2 μm filtered solution in Tris and NaCl containing 50 μg bovine serum albumin per 1 μg of cytokine.

Properties

recombinant

expressed in mouse NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

mol wt 66 kDa by SDS-PAGE (reducing and non-reducing conditions)

mol wt 66 kDa by SDS-PAGE

total impurities

Endotoxin, tested

Gene Information

human ... ANGPT2(285)

storage temp.

−20°C

References

Reference

Witzenbichler, B., Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J. Biol. Chem. 273, 18514, (1998) abstract

Safety

Safety Statements

22-24/25