B104
Sigma

tert-Butyl bicyclo[2.2.2]phosphorothionate

solid

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Synonym

TBPS

Molecular Formula

C₈H₁₅O₃PS

Molecular Weight

222.24

CAS Number

70636-86-1

MDL number

MFCD00168049

PubChem Substance ID

24891554

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Descriptions

Biochem/physiol Actions

GABA_A receptor antagonist; chloride channel blocker; extremely potent convulsant.

Preparation Note

Solutions may be stored for 1-2 days at 4 °C.

Properties

form

solid

color

white

solubility

DMSO: soluble

H₂O: Aqueous solubility may be enhanced by the use of non-ionic detergents (Brij, Tween) or 2-hydroxypropyl-β-cyclodextrin.slightly soluble

ethanol: soluble

storage temp.

2-8°C

References

Reference

Behrends, J.C., Modulation by bicuculline and penicillin of the block by t-butyl-bicyclo-phosphorothionate (TBPS) of GABA(A)-receptor mediated Cl⁻-current responses in rat striatal neurones. Br. J. Pharmacol. 129, 402, (2000) abstract

Poulter, M.O., Evidence that GABA_Areceptor subunit mRNA expression during development is regulated by GABA_A receptor stimulation. J. Neurochem. 68, 631, (1997) abstract

Tehrani, M.H, et al., Interaction of t-butylbicyclo-phosphorothionate with γ-aminobutyric acid-gated chloride channels in cultured cerebral neurons. J. Neurochem. 46, 1542-1548, (1986) abstract

Jursky, F., et al., Identification of amino acid residues of GABA(A) receptor subunits contributing to the formation and affinity of the tert-butylbicyclophosphorothionate binding site. J. Neurochem. 74, 1310-1316, (2000) abstract

Casida, et al., Bicycloorthocarboxylate convulsants. Potent GABA-A receptor antagonists. Mol. Pharmacol. 28, 246, (1985) abstract

Safety

WGK Germany

RTECS

TG0782500

Related Categories

... GABAergics > Antagonists

... Monovalent Ion Channels > Chloride Channel Modulators

... Ligand-Gated Ion Channels > GABA and Glycine Receptor Modulators

GABA A Receptors (186 kb)

MSDS

Certificate of Analysis

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