Bcl-2 human 

Solution in 20 mM Tris, pH 7.4, 250 mM NaCl, 1 mM EDTA, 1 mM DTT, 10% glycerol.

The Bcl-2 family of proteins serves as critical regulators of pathways involved in apoptosis, acting either to inhibit or to promote cell death. Bcl-2 has the ability to homodimerize or to heterodimerize with death promoting Bcl-2 family members. Its anti-apoptotic activity may be related to its phosphorylation state and could be related to prevention of pore formation in the mitochondrial membrane.

expressed in Escherichia coli (Maltose Binding Protein (MBP) fusion protein, C-terminal truncated)

≥80% (SDS-PAGE)

buffered aqueous glycerol solution

human ... BCL2(596)

dry ice

−70°C

Gross, A., et al. Genes Dev. 13, 1899, (1999) abstract

Reed, J.C. Oncogene 17, 3225, (1998) abstract

Blagosklonny, M.V. Leukemia 15, 869, (2001) abstract

Huang, Z. Oncogene 19, 6627, (2000) abstract

1