B1552
Sigma

Bromoenol lactone

≥98%

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Synonym

BEL

E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one

Molecular Formula

C₁₆H₁₃BrO₂

Molecular Weight

317.18

CAS Number

88070-98-8

MDL number

MFCD00270871

PubChem Substance ID

24278257

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Descriptions

Biochem/physiol Actions

Potent, irreversible inhibitor of calcium-independent phospholipase A₂ and of magnesium-dependent phosphatidate phosphohydrolase from P388D macrophages (IC₅₀ = 8 μM); enzyme activated irreversible chymotrypsin inhibitor (K_i = 636 nM).

Properties

assay

≥98%

solubility

DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble

degassed ethanol: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble

UV absorption

λ_max 224 nm

storage temp.

−20°C

References

Reference

Hazen. S.L., et al., Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A₂. J. Biol. Chem. 266, 7227-7232, (1991) abstract

Daniels, S.B., Haloenol lactones: potent enzyme-activated irreversible inhibitors for α-chymotrypsin. J. Biol. Chem. 258, 15046, (1983) abstract

Ackermann, E.J., Inhibition of macrophage Ca²⁺-independent phospholipase A₂ by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270, 445, (1995) abstract

Balsinde, J., Dennis, E.A., Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J. Biol. Chem. 271, 31937, (1996) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany