BAD from mouse 

Supplied as a solution in phosphate buffered saline containing 250 mM imidizole and 50% glycerol.

Bad, a pro-apoptotic factor, is a member of the Bcl-2 family. Cytokine-induced phosphorylation of Bad results in it being sequested in the cytosol. In the absence of cytokines such as interleukin 3 (IL-3), Bad dephosphorylation occurs, causing the release of cytochrome c from the mitochondria.

expressed in Escherichia coli

full-length murine Bad with an N-terminal histidine-tag.

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

mol wt 31 kDa

mouse ... Bad(12015)

−20°C

Scheid, MP, et. al. J. Biol. Chem. 274, 31108, (1999)

Datta, S.R., et al. Cell 91, 231, (1997)

Zha, J., et al. Cell 87, 619, (1996)

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