BIO 

Store in the dark under nitrogen. Product is light- and air-sensitive.

6-bromoindirubin-3'-oxime (BIO) is a potent, reversible and ATP-competitive GSK-3α/β inhibitor and the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Human embryonic stem cells (hESCs) are maintained in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition.

Product is sold for research and laboratory purposes in-vitro and may not be used for any in-vivo or therapeutic uses in humans, veterinary applications, or to make chemical derivatives.

≥98% (HPLC)

solid

dark red

DMSO: >5 mg/mL

wet ice

2-8°C

Polychronopoulos, P. et al. J. Med. Chem. 47, 935-946 , (2004)

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