B2559
Sigma

B581

>95% (HPLC), solid

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Synonym

N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt

Amino Acid Sequence

Cys-(R)-Val-(R)-Phe-Met

Molecular Formula

C₂₂H₃₈N₄O₃S₂

Molecular Weight

470.69

CAS Number

149759-96-6

MDL number

MFCD00236999

PubChem Substance ID

24891659

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Descriptions

Biochem/physiol Actions

Stable and membrane permeable. Inhibitor of farnesyltransferase.

Packaging

Packaged under nitrogen and with desiccant.

Properties

assay

>95% (HPLC)

form

solid

composition

Peptide content, ~60%

color

white

solubility

H₂O: soluble

Gene Information

rat ... Fnta(25318)

storage temp.

−20°C

References

Reference

Cox, AD., et al, The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J. Biol. Chem. 269, 19203-19206, (1994)

Safety

Safety Statements

22-24/25

WGK Germany

Related Categories

... G Protein Function > Post-translational Modification

Protein Prenyltransferases (182 kb)

MSDS

Certificate of Analysis

More Information

Related Categories

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