Betacellulin human 

The bioactivity is measured in a cell proliferation assay using BALB/3T3 fibroblasts.

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing bovine serum albumin.

Betacellulin, a heparin-binding member of the EGF family, appears to play a role in the growth and differentiation of islet cells in human pancreas. BTC binds with high affinity to both EGFR and to erbB-4. Overexpression of BTC with erbB-3 and erbB-4 are linked to human endometrial adenocarcinoma. Human and mouse precursor forms of BTC show 79% amino acid sequence identity.

expressed in Escherichia coli

≥97% (SDS-PAGE)

lyophilized powder

protein mol wt 9.5 kDa

Endotoxin, tested

cell culture tested

human ... BTC(685)

−20°C

Miyagawa, J., et al., Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells. Endocrine J. 46, 755-764, (1999)

Riese, D., et al., Betacellulin activates the epidermal growth factor receptor and erbB-4 and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulinβ. Oncogene 12, 345, (1996) abstract

Srinivasan, R., et al., Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Clin. Cancer Res. 5, 2877-2883, (1999) abstract

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