B4556
Sigma

Biology of Phosphoinositides

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General description

This review of current lipid signaling research places emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. The regulation of phospholipase C, phospholipase D, phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are covered in depth. There is specific discussion of the PH and FYVE lipid domains that allow lipids to control the movement, location, and activation-state of membrane proteins.

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Identifiers

ISBN-10

0-19-963764-4

ISBN-13

978-0-19-963764-5

Properties

publication info

S. Cockcroft, ed., Oxford University Press, 2000, 368 pp., soft cover

Table of Contents

Regulation of Phosphoinositide-specific Phospholipase C isozymes Phosphoinositide- 3-kinases - Regulation by cell surface receptors and function of 3-phosphorylated lipids Enzymes involved in the synthesis of phosphatidylinositol 4,5 bisphosphate and their regulation - Phosphoinositide kinases Pleckstrin Homology Domains: Phosphoinositide-regulated membrane tethers Regulation of cytoskeletal protein by inositol lipids Physiological functions phosphatidylinositol transfer proteins Glycosyl-phosphatidylinositol anchored proteins and their phospholipases Phosphatidylinositol 3 kinase and membrane traffic Regulation of Phospholipase D signaling by phosphoinositides Regulation of chloride channel conductance by inositol (3,4,5,6) tetraphosphate; A phosphoinositide-initiated signaling pathway that acts downstream of inositol (1,4,5) trisphosphate Phosphatases for inositol lipids and for inositol phosphates