B5057
Sigma

7-Benzyloxy-4-trifluoromethylcoumarin

≥99% (HPLC), solid

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Molecular Formula

C₁₇H₁₁F₃O₃

Molecular Weight

320.26

MDL number

MFCD01564466

PubChem Substance ID

24891807

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Descriptions

Biochem/physiol Actions

Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.

Legal Information

Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.

Properties

assay

≥99% (HPLC)

form

solid

storage temp.

−20°C

References

Reference

Renwick, A. B., Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30, 955, (2000)

Lu, P., et al., Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4. Drug Metab. Dispos. 29(11), 1473-1479, (2001)

Arora, V., et al., Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism. Drug Metab. Dispos. 30(7), 757-762, (2002)

Safety

Safety Statements

22-24/25

WGK Germany