B5416
Sigma

8-Bromo-cyclic adenosine diphosphate ribose

85% (HPLC), lyophilized powder

Synonym

Br-cADP-ribose

Br-cADPR

Molecular Formula

C₁₅H₂₀BrN₅O₁₃P₂

Molecular Weight

620.20

CAS Number

151898-26-9

MDL number

MFCD00274402

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Descriptions

Biochem/physiol Actions

An antagonist of cyclic ADP-ribose (cADPR), and an endogenous metabolite of β-NAD⁺. cADPR has been shown to regulate calcium release from the endoplasmic and sarcoplasmic reticulum. In cells, cADPR is synthesized by ADP-ribosyl cyclase or CD38, a lymphocyte differentiation antigen.

Preparation Note

Prepared enzymatically

Physical form

Lyophilized powder containing 10-20% sodium phosphate buffer salts

Properties

assay

85% (HPLC)

form

lyophilized powder

color

white

solubility

H₂O: 5 mg/mL

storage temp.

−20°C

References

Reference

Lee, H.C., Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration. Cell Biochem. Biophys. 28, 1-17, (1998) abstract

Guse, A.H., et al., Characterization of cyclic adenosine diphosphate-ribose-induced Ca²⁺ release in T lymphocyte cell lines. J. Immunol. 155, 3353, (1995) abstract

Walseth, T.F., Lee, H.C., Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca²⁺ release. Biochim. Biophys. Acta 1178, 235, (1993) abstract

De Flora, A., et al., The CD38/cyclic ADP-ribose system: a topological paradox. Int. J. Biochem. Cell Biol. 29, 1149-1166, (1997) abstract

Lee, H.C., et al., ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca⁺² signaling. Adv. Exp. Med. Biol. 419, 411, (1997) abstract

Lahouratate, P., et al., cADP-ribose releases Ca²⁺ from cardiac sarcoplasmic reticulum independently of ryanodine receptor. Am. J. Physiol. 273(3 Pt 2), H1082-H1089, (1997)

Iino, S., et al., Actions of cADP-ribose and its antagonists on contraction in guinea pig isolated ventricular myocytes. Influence of temperature. Circ. Res. 81, 879-884, (1997) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany