| B6308 Sigma |
Biochemistry of Cell Signalling |
General description
This will serve as a reliable map through the maze of cell signaling pathways and help the reader understand how malfunctions in these pathways can lead to disease. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. Part 2 describes the implementation of the signaling cascades focusing on the effect on gene transcription. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer.
Table of Contents
Part I: The machinery of signal transduction 1. Molecular basis of signal transduction
2. Activation of receptors by oligomerization
3. Components of signaling networks: linkers and regulators
4. Signal transduction pathways through small monomeric G proteins
5. Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals
6. Signal transduction pathways through morphogenesis and haematopoiesis
7. Control of signaling by phosphorylation and dephosphorylation
8. Regulation by a hormone: the insulin response
Part II: Cell Signaling and gene transcription 9. Machinery of Gene transcription
10. Regulation of gene transcription by growth factors and cytokines
11. Regulation of gene transcription by hormones
Part III: Global cell regulatory programs 12. Regulation of the cell cycle
13. Regulation of cell death
14. Regulation of the immune response
Part IV: Loss of regulatory control and its consequences
15. Transformation of normal cells to tumour cells
16. Loss of developmental controls in cancer
17. The causes of cancer
Glossary
2. Activation of receptors by oligomerization
3. Components of signaling networks: linkers and regulators
4. Signal transduction pathways through small monomeric G proteins
5. Signal transduction pathways through heterotrimeric G proteins: transmission of hormonal and sensory signals
6. Signal transduction pathways through morphogenesis and haematopoiesis
7. Control of signaling by phosphorylation and dephosphorylation
8. Regulation by a hormone: the insulin response
Part II: Cell Signaling and gene transcription 9. Machinery of Gene transcription
10. Regulation of gene transcription by growth factors and cytokines
11. Regulation of gene transcription by hormones
Part III: Global cell regulatory programs 12. Regulation of the cell cycle
13. Regulation of cell death
14. Regulation of the immune response
Part IV: Loss of regulatory control and its consequences
15. Transformation of normal cells to tumour cells
16. Loss of developmental controls in cancer
17. The causes of cancer
Glossary
Related Information
Links
Page Options| |
|
© 2008 Sigma-Aldrich Co. Reproduction forbidden without permission. |