B6811
Sigma

(+)-Bicuculline

≥98%, crystalline

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Replaced by

14340, (+)-Bicuculline

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Molecular Formula

C₂₀H₁₇NO₆

Molecular Weight

367.35

CAS Number

485-49-4

Beilstein Registry Number

98786

MDL number

MFCD00005006

EG/EC Number

207-619-7

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Descriptions

Biochem/physiol Actions

(+)-Bicuculline is a GABA_A receptor antagonist.

Properties

assay

≥98%

form

crystalline

color

pale yellow

195-199 °C

solubility

chloroform: soluble

Gene Information

rat ... Gabra2(29706)

storage temp.

2-8°C

References

Reference

Avoli, M., et al., Functional and pharmacological properties of GABA-mediated inhibition in the human neocortex. Can. J. Physiol. Pharmacol. 75, 526, (1997)

Strobaek, D., et al., Pharmacological characterization of small-conductance Ca²⁺-activated K⁺ channels stably expressed in HEK 293 cells. Br. J. Pharmacol. 129, 991, (2000) abstract

Johnson, S.W., Seutin, V., Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca²⁺-activated K⁺ currents. Neurosci. Lett. 231, 13, (1997)

Chebib, M., Johnston, G.A., The 'ABC' of GABA receptors: a brief review. Clin. Exp. Pharmacol. Physiol. 26, 937, (1999)

Merck

Merck 13,1207

Beilstein

Beil. 27,IV,6900

Safety

Hazard Codes

T,N

Risk Statements

23/24/25-50

Safety Statements

36/37-45-61

RIDADR

UN 1544 6.1/PG 2

WGK Germany

RTECS

LV0909840

10-23

MSDS

Certificate of Analysis

More Information