B7059
Sigma

Monoclonal Anti-Breast Cancer Resistance Protein antibody produced in mouse

250 μg/mL, clone BXP-21, tissue culture supernatant, aqueous solution

Synonym

Anti-ABCG2

Anti-BCRP

MDL number

MFCD03791618

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Descriptions

Immunogen

fusion protein containing human BCRP (amino acids 271-396) and maltose-binding protein.

Specificity

Reacts with an internal epitope of BCRP. Does not cross-react with the human MDR1, MRP1, MRP2 gene products.

Physical form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Properties

antibody form

tissue culture supernatant

clone

BXP-21

form

aqueous solution

mol wt

antigen mol wt ~70 kDa

species reactivity

human

concentration

250 μg/mL

application(s)

immunoblotting: suitable

immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable using pretreated human tissue

immunohistochemistry (frozen sections): 1:20 using acetone-fixed frozen sections

isotype

IgG2a

Gene Information

human ... ABCG2(9429)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Doyle, L.A., et al., A multidrug resistance transporter from human MCF-7 breast cancer cells [erratum in PNAS USA 1999; 96(5):2569]. . Proc. Natl. Acad. Sci. USA 95, 15665-15670, (1998) abstract

Maliepaard, M., et al., Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61, 3458-3464, (2001) abstract

Scheffer, G.L., et al., Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res. 60, 2589-2593, (2000) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

WGK Germany