B7684
Sigma

Monoclonal Anti-Breast Cancer Resistance Protein antibody produced in mouse

250 μg/mL, clone BXP-34, tissue culture supernatant, aqueous solution

Synonym

Anti-ABCG2

Anti-BCRP

MDL number

MFCD03791618

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Descriptions

Immunogen

mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR.

Specificity

Reacts with an internal epitope of BCRP. Does not react with the human MDR1, MRP1, MRP2, MRP5 gene products.

Physical form

Solution in serum-free culture medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Properties

antibody form

tissue culture supernatant

clone

BXP-34

form

aqueous solution

mol wt

antigen mol wt ~70 kDa

species reactivity

human

concentration

250 μg/mL

application(s)

immunoblotting: Not suitable

immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations

immunohistochemistry (formalin-fixed, paraffin-embedded sections): Not suitable

immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections

isotype

IgG1

Gene Information

human ... ABCG2(9429)

shipped in

dry ice

storage temp.

−20°C

References

Reference

Scheffer, G.L., et al., Breast cancer resistance protein is localized at the plasma membrance in mitoxantrone- and topotecan-resistant cell lines. Cancer Res. 60, 2589-2593, (2000) abstract

Scheffer, G.L., et al., Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 p-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 60, 5269-5277, (2000) abstract

Doyle, L.A., A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. USA 95, 15665-15670, (1998) abstract

Safety

WGK Germany

Related Categories

... Cancer Markers and Antibodies > Antibodies

... Antibodies for Multi-Drug Resistance > Antibodies to Drug Efflux Pumps

... Alphabetical Index > B

... Clone Index > B

... Multidrug Resistance > Multidrug Resistance Antibodies

... Tumor Growth Regulation > Steroid Sensitive Cancer Markers

B7684 - Datasheet (26kb)

MSDS

Certificate of Analysis

More Information