C0256
Sigma

Cytidine 5′-diphosphocholine sodium salt dihydrate

~98%, from yeast, solid

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Synonym

CDP-choline-Na

CDP-coline

Citicoline sodium

P'-[2-(Trimethylammonio)ethyl]ester cytidine 5'-(trihydrogen diphosphate) inner salt monosodium

Molecular Formula

C₁₄H₂₅N₄NaO₁₁P₂ · 2H₂O

Molecular Weight

546.34

CAS Number

33818-15-4

Beilstein Registry Number

4110040

MDL number

MFCD00150508

PubChem Substance ID

24278064

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Descriptions

Biochem/physiol Actions

Neuroprotective in situations of hypoxia and ischemia; biosynthetic intermediate of membrane phospholipids; cerebral vasodilator; inhibits PLA₂ activation.

Caution

Hygroscopic

Properties

biological source

from yeast

assay

~98%

form

solid

color

white

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

References

Reference

Onal, et al., Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke 28, 1060-1065, (1997) abstract

Schabitz, et al., The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J. Neurol. Sci. 38, 21-25, (1996)

Clark, et al., A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. Neurology 49, 671-678, (1997) abstract

Merck

Merck 13,2343

Beilstein

Beil. 25,IV,3676

Safety

WGK Germany

3-10-21