C0869
Sigma

Celastrol

≥98% (HPLC), solid

1 of 1

Synonym

Tripterin

10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid

Molecular Formula

C₂₉H₃₈O₄

Molecular Weight

450.61

CAS Number

34157-83-0

MDL number

MFCD03424073

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Descriptions

Biochem/physiol Actions

Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Properties

assay

≥98% (HPLC)

form

solid

color

red

solubility

DMSO: >10 mg/mL

H₂O: insoluble

storage temp.

−20°C

References

Reference

Huang, Y. et al., Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett. 264, 101-106, (2008)

Jung, H.W., et al., Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells. Exp. Mol. Med. 39, 715-721, (2007)

Zhang, T. et al., A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther. 7, 162-170, (2008)

Safety

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany