(2-Hydroxypropyl)-β-cyclodextrin 

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

Solutions may be stored for several months at 4°C. Solid should be stored tightly sealed at room temperature.

powder

4-10 (determined by NMR)

H₂O: 100 mg/mL

cell culture tested

Rekharsky, M.K., et al., Complexation thermodynamics of cyclodextrins. Chem. Rev. 98, 2045-2076, (1998) abstract

3

GU2293332