C104
Sigma

(±)-CPP

solid

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Synonym

(±)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid

Molecular Formula

C₈H₁₇N₂O₅P

Molecular Weight

252.20

CAS Number

100828-16-8

MDL number

MFCD00055136

PubChem Substance ID

24277958

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Descriptions

Biochem/physiol Actions

Potent and selective NMDA glutamate receptor antagonist; anticonvulsant.

Caution

Hygroscopic

Properties

form

solid

color

white

solubility

H₂O: 99.2 mg/mL

ethanol: insoluble

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

rat ... Grin2a(24409)

References

Reference

Murphy, et al., Binding of [³H]-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid to rat brain membranes: a selective high affinity ligand for N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 240, 778, (1987) abstract

Turski, et al., Muscle relaxant and anticonvulsant activity of 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents. Neurosci. Lett. 73, 143-148, (1987) abstract

Lehman, et al., CPPA selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo. J. Pharmacol. Exp. Ther. 240, 737-746, (1987) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-26-36

WGK Germany

Related Categories

... Ligand-Gated Ion Channels > Ionotropic Glutamate Receptor Modulators

... Excitatory Amino Acids > NMDA Antagonists

MSDS

Certificate of Analysis

Certificate of Origin

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