C141
Sigma

CGS-21680 hydrochloride hydrate

solid

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Synonym

2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate

Molecular Formula

C₂₃H₂₉N₇O₆ · HCl · xH₂O

Molecular Weight

535.98 (anhydrous basis)

CAS Number

124182-57-6

PubChem Substance ID

24277698

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Descriptions

Caution

Hygroscopic

Biochem/physiol Actions

Adenosine receptor agonist, which possesses selectivity for A₂ verses A₁ receptors.

Legal Information

Manufactured and sold in the USA with the exclusive permission of Novartis Pharma AG, U.S. Patent 4,968,697.

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

Gene Information

human ... ADORA2A(135), ADORA2B(136)

storage temp.

−20°C

References

Reference

Jarvis, et al., [³H]CGS 21680 a selective A₂ adenosine receptor agonist directly labels A₂ receptors in rat brain. J. Pharmacol. Exp. Ther. 251, 888, (1989) abstract

Phillis, et al., The selective adenosine A₂ receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res. 509, 328-330, (1990) abstract

Levens, et al., Renal actions of a new adenosine agonist CGS 21680A selective for the A₂ receptor. J. Pharmacol. Exp. Ther. 257, 1005, (1991) abstract

Safety

Safety Statements

22-24/25

WGK Germany

Related Categories

... Adenosines/P2 Nucleotide Receptors (Purinergics) > Agonists

Adenosine Receptors (193 kb)

Celltransmissions 19(4) (178kb)

MSDS

Certificate of Analysis

More Information