Cyclosporin A 

Tested for inhibition of interleukin 2 production by Jurkat cells.

Potent immunosuppressive agent, inhibiting primarily T lymphocytes.

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

from Tolypocladium inflatum

for molecular biology

≥95%

2-8°C

Kronke, M., et al., Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA 81, 5214-5218, (1984) abstract

Donjerkovic, et al., Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium. Cell. Growth Differ. 10, 695-704, (1999)

Mordvinov, et al., A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. J. Immunol. Methods 228, 163-168, (1999)

Pritchard, D.E., et al., Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis 21, 2027-2033, (2000)

Zaidan, et al., Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J. Neurochem. 73, 2214-2217, (1999)

Manger, G., et al., Differential effect of cyclosporin A on activation signaling in human T cell lines. J. Clin. Invest. 77, 1501-1506, (1986) abstract

Merck 13,2781

3

GZ4120000