C277
Sigma

Chloro-IB-MECA

solid, ≥98% (HPLC)

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Synonym

Cl-IB-MECA

2-Chloro-N⁶-(3-iodobenzyl)-adenosine-5′-N-methyluronamide

Molecular Formula

C₁₈H₁₈ClIN₆O₄

Molecular Weight

544.73

CAS Number

163042-96-4

MDL number

MFCD01323055

PubChem Substance ID

24278354

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Descriptions

Biochem/physiol Actions

A₃ adenosine receptor agonist.

Properties

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)

rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

References

Reference

Dunwiddie, T.V., et al., Activation of hippocampal adenosine A₃ receptors produces a desensitization of A₁receptor-mediated responses in rat hippocampus. J. Neurosci. 17, 607-614, (1997) abstract

Stambaugh, K., et al., A novel cardioprotective function of adenosine A₁ and A₃ receptors during prolonged simulated ischemia. Am. J. Physiol. 273, H501-H505, (1997) abstract

Yao, Y., et al., Adenosine A₃ receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A₃ antagonists. Biochem. Biophys. Res. Commun. 232, 317, (1997) abstract

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany