C2899
Sigma

Cytisine

≥99%, powder

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Synonym

(−)-Cytisine

Molecular Formula

C₁₁H₁₄N₂O

Molecular Weight

190.24

CAS Number

485-35-8

MDL number

MFCD00136048

PubChem Substance ID

24892544

EG/EC Number

207-616-0

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Descriptions

Biochem/physiol Actions

Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.

Properties

assay

≥99%

form

powder

color

light yellow

218 °C/2 mmHg(lit.)

154-156 °C(lit.)

Gene Information

rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590)

References

Reference

Carbonnelle, E., et al., Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur. J. Pharmacol. 471, 85-96, (2003)

Free, R.B., et al., Pharmacological characterization of recombinant bovine α3βeta4 neuronal nicotinic receptors stably expressed in HEK 293 cells. Neurosci. Lett. 343, 180-184, (2003)

Zhang, J., and Steinbach, J.H., Cytisine binds with similar affinity to nicotinic α4β2 receptors on the cell surface and in homogenates. Brain Res. 959, 98-102, (2003)

Merck

Merck 13,2818

Beilstein

Beil. 24,134

reference

FT-IR 2 (1), 1381:A / FT-NMR 1 (1), 1324:B / RegBook 1 (1), 957:B / Sax 6, 850 / Structure Index 1, 148:A:8

Safety

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-28-36/37-45