C2932
Sigma

Chelerythrine chloride

~95% (TLC), powder

zoom

1 of 1

Synonym

1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

Molecular Formula

C₂₁H₁₈ClNO₄

Molecular Weight

383.82

CAS Number

3895-92-9

MDL number

MFCD00060717

PubChem Substance ID

24278305

EG/EC Number

223-444-9

Expand/Collapse All

Descriptions

Biochem/physiol Actions

Chelerythrine affects translocation of PKC from cytosol to plasma membrane. Shown to prevent neurite growth. Induces apoptosis in a concentration- and schedule-dependent manner.

Properties

assay

~95% (TLC)

form

powder

color

yellow to orange

solubility

DMSO: ≥10 mg/mL

H₂O: 5 mg/mL

storage temp.

−20°C

References

Reference

Herbert, J.M., et al., Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 172, 993-999, (1990) abstract

Hiruma, H., et al., Axonal transport is inhibited by a protein kinase C inhibitor in cultured isolated mouse dorsal root ganglion cells. Brain Res. 826, 135-138, (1999) abstract

Eckly-Michel, A.E., Chelerythrine a protein kinase C inhibitor interacts with cyclic nucleotide phosphodiesterases. Eur. J. Pharmacol. 324, 5, (1997)

Chao, M.D., et al., Inhibition of protein kinase C translocation from cytosol to membrane by chelerythrine. Planta Med. 64, 662-663, (1998) abstract

Freemerman, A.J., et al., Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. Mol. Pharmacol. 49, 788-795, (1996) abstract

Jarvis, W.D., et al., Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54, 1707-1714, (1994) abstract

Safety

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

FL9200000