Monoclonal Anti-Cathepsin L antibody produced in mouse 

procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.

ascites fluid

33/2

antigen (human cathepsin L) mol wt 25 kDa

antigen (human procathepsin L) mol wt 42 kDa

15 mM sodium azide

human, rat, mouse, mink

immunoblotting: 1:200 using whole cell extract of a cultured mink lung cell line

immunohistochemistry (frozen sections): suitable

indirect ELISA: suitable

microarray: suitable

IgG1

mouse ... Ctsl(13039)

human ... CTSL1(1514)

rat ... Ctsl(25697)

dry ice

−20°C

Weber, E., et al. Hybridoma 16, 159, (1997) abstract

3

C4618, Monoclonal Anti-Cathepsin L antibody produced in mouse

C6854, Cathepsin L from human liver

XP725, Panorama^® Antibody Microarray - XPRESS Profiler725 Kit