Cytochrome c from equine heart 

Shows a high rate of ascorbic acid oxidation and low enzymatic activity in a cytochrome oxidase system; contains inactive cytochrome polymers which can be converted back to native cytochrome.¹

Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell.

This is essentially “Fraction II, pH 7” of Margoliash² prepared using TCA.

~90% based on Mol. Wt. 12,384 basis

−20°C

1. Schejter, A., et al. Biochim. Biophys. Acta 73, 641, (1963) abstract

2. Margoliash, E. Biochem. J. 56, 535, (1954) abstract

Merck 13,2820

3

HA5365000