Cell Adhesion 

0-19-963871-3

978-0-19-963871-0

M.C. Beckerle, ed., Oxford University Press, 2001, 384 pp., soft cover

PART 1: The immunoglobulin superfamily of cell adhesion molecules,
1. Introduction 2. Structure of IgCAMs 3. Expression of IgCAMs 4. Extracellular interactions of IgCAMs 5. Intracellular interactions of IgCAMs with cytoskeletal components 6. Signaling of IgCAMs 7. IgCAM function in vivo 8. L1 and pathogenesis 9. Emerging concepts
PART 2: Selectins,
1. Introduction 2. Structure of selectins 3. Selectin ligands 4. Mechanisms for selectin-mediated cell adhesion under flow conditions 5. Regulation of expression of selectins and selectin ligands 6. Signaling through selectins or selectin ligands 7. Functions of selectins in vivo 8. Contributions of selectins to disease 9. Conclusions References
PART 3: Cadherins,
1. Introduction 2. Molecular architecture of a cadherin 3. Developmental regulation of cadherin subtypes 4. Mutational analysis of the cadherin/catenin adhesion complex in invertebrates 5. Genetic analysis of cadherin/catenin complex in mice 6. Role of cadherins in cancer 7. Genetic regulation of cadherin function 8. Cadherin-mediated adhesion and tissue differentiation 9. Cadherins and cell survival 10. Conclusions
PART 4: The integrin family of cell adhesion molecules,
1. Introduction 2. Integrin structure and ligand binding functions 3. Integrin signaling 4. Cell biological consequences of integrin functions 5. Integrins in development 6. Integrins in disease 7. Emerging concepts and perspectives References
PART 5: Cell surface heparan sulfate proteoglycans,
1. Introduction 2. A primer on heparan sulfate 3. Cell surface haparan sulfate proteoglycan core proteins 4. Cell adhesion mediated by cell surface heparan sulfate proteoglycans 5. Cellular consequences of HSPG-mediated adhesion 6. Consequence of altered heparan sulfate proteoglycan cell adhesions 7. Future prospects s
PART 6: ADAMs,
1. Introduction 2. Molecular structure of the ADAMs 3. Disintegrin domains 4. ADAM family tree 5. Integrins as co-receptors for ADAMs 6. The cysteine-rich domain: possible roles in cell adhesion 7. ADAMs in development 8. ADAMs in disease 9. Remaining questions References
PART 7: Protein tyrosine phosphatases,
1. Introduction 2. Molecular structure 3. Expression pPatterns 4. Role in cell adhesion 5. Regulation of the enzymatic function of RPTPs 6. Identification of RPTP-dependent signaling pathways 7. Physiological functions of RPTPs 8. Emerging concepts
PART 8: The adherens junction,
1. Introduction 2. Ultrastructure 3. Description of junctional components 4. Role of junctional components in cell adhesion 5. Assembly of junctions 6. Communication between the junctional complex and the nucleus via catenins 7. Emerging concepts
PART 9: Focal adhesions and focal complexes,
1. Introduction 2. In situ focal adhesion homologues 3. Assembly and maturation of focal complexes and focal adhesions 4. Integrin-cytoskeletal links 5. Hierarchial structure of focal adhesions 6. Integrin-mediated signaling and focal adhesions 7. Syndecan-4-mediated signaling and foical adhesions 8. Concluding remarks
PART 10: Desmosomes and hemidesmosomes,
1. Introduction 2. The desmosome 3. The hemidesmosome 4. Conclusion Acknowledgements References
PART 11: The tight junction
1. Overview: structure and functions of tight junctions 2. Integral membrane proteins constituting tight junction strands 3. Peripheral membrane proteins underlying tight junctions 4. A possible model for the molecular architecture of tight junctions 5. Formation and destruction of tight junctions in epithelial cells 6. Regulation of tight junction functions 7. Signaling events at the cytoplasmic surface of tight junctions 8. Conclusions