C4382
Sigma

Carbamoylcholine chloride

≥98% (titration), crystalline

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Synonym

(2-Hydroxyethyl)trimethylammonium chloride carbamate

Carbachol

Carbamylcholine chloride

Molecular Formula

NH₂COOCH₂CH₂N(Cl)(CH₃)₃

Molecular Weight

182.65

CAS Number

51-83-2

Beilstein Registry Number

3917459

MDL number

MFCD00012011

PubChem Substance ID

24277829

EG/EC Number

200-127-3

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Descriptions

Frequently Asked Questions

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Biochem/physiol Actions

Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Properties

assay

≥98% (titration)

form

crystalline

color

white

210 °C (dec.)(lit.)

solubility

H₂O: 1 g/mL

ethanol: 20 mg/mL

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), CHRNA2(1135)

mouse ... Chrm1(12669)

rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Chrna2(170945), Chrna3(25101), Chrna4(25590)

References

Reference

Yan, G.M., et al., Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Pharmacol. 47, 248-257, (1995) abstract

Yamada, T., et al., Muscarinic acetylcholine receptors on rat thymocytes: their possible involvement in DNA fragmentation. Jpn. J. Pharmacol. 73, 311-316, (1997) abstract

Pugh, P.C., and Margiotta, J.F., Nicotinic acetylcholine receptor agonists promote survival and reduce apoptosis of chick ciliary ganglion neurons. Mol. Cell. Neurosci. 15, 113-122, (2000) abstract

Merck

Merck 13,1786

Beilstein

Beil. 4,IV,1455

reference

Aldrich MSDS 1, 348:A / Corp MSDS 1 (1), 680:B / FT-IR 2 (1), 1303:D / FT-IR 1 (1), 773:D / FT-NMR 1 (1), 1261:B / IR-Spectra (3), 452:B / IR-Spectra (2), 400:A / NMR-Reference 2 (1), 649:C / RegBook 1 (1), 907:F / Sax 6, 631 / Sigma FT-IR 1 (2), 7:B / Structure Index 1, 139:C:8

Safety

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 2

WGK Germany

RTECS

GA0875000